Impact of Smoothing on Parameter Estimation in Quantitative DNA Amplification Experiments
نویسندگان
چکیده
منابع مشابه
Impact of smoothing on parameter estimation in quantitative DNA amplification experiments.
BACKGROUND Quantification cycle (Cq) and amplification efficiency (AE) are parameters mathematically extracted from raw data to characterize quantitative PCR (qPCR) reactions and quantify the copy number in a sample. Little attention has been paid to the effects of preprocessing and the use of smoothing or filtering approaches to compensate for noisy data. Existing algorithms largely are taken ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2015
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2014.230656